Helminth allergens, parasite-specific IgE, and its protective role in human immunity

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Front. Immunol., 14 February 2014 | doi: 10.3389/fimmu.2014.00061 Colin Matthew Fitzsimmons1†, Franco Harald Falcone2*† and David William Dunne1 1Department of Pathology, University of Cambridge, Cambridge, UK 2School of Pharmacy, University of Nottingham, Nottingham, UK.

 The Th2 immune response, culminating in eosinophilia and IgE production, is not only characteristic of allergy but also of infection by parasitic worms (helminths). Anti-parasite IgE has been associated with immunity against a range of helminth infections and many believe that IgE and its receptors evolved to help counter metazoan parasites....

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